| # | Player Name | Date of Birth | Nationality | Apps | Start | Sub | Bench | Goals | Yellow | Red |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | VAN DER SAR Edwin | 29/10/1970 | Dutch | 33 | 33 | 0 | 1 | 0 | 1 | 0 |
| 2 | NEVILLE Gary | 18/02/1975 | English | 3 | 3 | 0 | 2 | 0 | 1 | 0 |
| 3 | EVRA Patrice | 15/05/1981 | French | 35 | 34 | 1 | 2 | 1 | 1 | 0 |
| 4 | HARGREAVES Owen | 20/01/1981 | English | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 5 | FERDINAND Rio | 07/11/1978 | English | 19 | 19 | 0 | 1 | 0 | 0 | 0 |
| 6 | BROWN Wes | 13/10/1979 | English | 7 | 4 | 3 | 7 | 0 | 2 | 0 |
| 7 | OWEN Michael | 14/12/1979 | English | 11 | 1 | 10 | 11 | 2 | 1 | 0 |
| 8 | ANDERSON | 13/04/1988 | Brazilian | 18 | 14 | 4 | 6 | 1 | 2 | 0 |
| 9 | BERBATOV Dimitar | 30/01/1981 | Bulgarian | 32 | 24 | 8 | 2 | 20 | 1 | 0 |
| 10 | ROONEY Wayne | 24/10/1985 | English | 28 | 25 | 3 | 0 | 11 | 5 | 0 |
| 11 | GIGGS Ryan | 29/11/1973 | Welsh | 25 | 19 | 6 | 2 | 2 | 5 | 0 |
| 12 | SMALLING Chris | 22/11/1989 | English | 16 | 11 | 5 | 17 | 0 | 0 | 0 |
| 13 | Ji-Sung PARK | 25/02/1981 | South Korean | 15 | 13 | 2 | 3 | 5 | 1 | 0 |
| 14 | HERNANDEZ Javier | 01/06/1988 | Mexican | 27 | 15 | 12 | 6 | 13 | 5 | 0 |
| 15 | VIDIC Nemanja | 21/10/1981 | Serbian | 35 | 35 | 0 | 0 | 5 | 7 | 1 |
| 16 | CARRICK Michael | 28/07/1981 | English | 28 | 23 | 5 | 3 | 0 | 1 | 0 |
| 17 | NANI | 17/11/1986 | Portuguese | 33 | 31 | 2 | 1 | 9 | 1 | 0 |
| 18 | SCHOLES Paul | 16/11/1974 | English | 22 | 16 | 6 | 4 | 1 | 9 | 0 |
| 20 | da Silva FABIO | 09/07/1990 | Brazilian | 11 | 5 | 6 | 7 | 1 | 2 | 0 |
| 21 | da Silva RAFAEL | 09/07/1990 | Brazilian | 16 | 15 | 1 | 9 | 0 | 3 | 1 |
| 22 | O'SHEA John | 30/04/1981 | Irish | 20 | 18 | 2 | 7 | 0 | 1 | 0 |
| 23 | EVANS Jonny | 03/01/1988 | Irish | 13 | 11 | 2 | 9 | 0 | 2 | 1 |
| 24 | FLETCHER Darren | 01/02/1984 | Scottish | 26 | 24 | 2 | 1 | 2 | 3 | 0 |
| 25 | VALENCIA Luis Antonio | 04/08/1985 | Ecuadorian | 10 | 8 | 2 | 2 | 1 | 1 | 0 |
| 26 | OBERTAN Gabriel | 06/02/1989 | French | 7 | 3 | 4 | 6 | 0 | 0 | 0 |
| 27 | MACHEDA Federico | 22/08/1991 | Italian | 7 | 2 | 5 | 5 | 1 | 0 | 0 |
| 28 | GIBSON Darron | 25/10/1987 | Irish | 12 | 6 | 6 | 10 | 0 | 3 | 0 |
| 29 | KUSZCZAK Tomasz | 20/03/1982 | Polish | 5 | 5 | 0 | 27 | 0 | 0 | 0 |
| 33 | BEBE | 12/07/1990 | Portuguese | 2 | 0 | 2 | 3 | 0 | 0 | 0 |
| 34 | LINDEGAARD Anders | 13/04/1984 | Danish | 0 | 0 | 0 | 4 | 0 | 0 | 0 |
| 40 | AMOS Ben | 10/04/1990 | English | 0 | 0 | 0 | 6 | 0 | 0 | 0 |
| 41 | KING Joshua | 15/01/1992 | Norwegian | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 45 | GILL Oliver | 15/09/1990 | English | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
| Own Goals | 3 | |||||||||
| Totals | 517 | 418 | 99 | 167 | 78 | 58 | 3 | |||